The 454 Casull is a bit stiffer than 44 Magnum, noticeably so. However, one can fire 45 Colt in the 454 Casull much the same as 44 Spl in 44 Mag, and 38 Spl in 357 Mag.

454 Casull ammo tends to be a bit Cha-CHING! if one doesn't reload.

Noah