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  1. #11
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    Default Re: Texas Chronic Wasting Disease CWD TSE Prion Symposium 2018 posted January 2019 VI

    Quote Originally Posted by Delkal View Post
    The scary part about prion diseases is that it is impossible to sterilize an infected area. Even at the deer farms once it is in an area it is there forever. That dead carcass or even the dirt next a that pile of poop could be infectious for years. Its not going to ever go away and WILL spread........no matter what we do.

    The much bigger question is can humans get it from eating the deer.

    indeed, very scary. think plague in slow motion...

    ***> This is very likely to have parallels with control efforts for CWD in cervids.

    Rapid recontamination of a farm building occurs after attempted prion removal

    http://dx.doi.org/10.1136/vr.105054

    Kevin Christopher Gough, BSc (Hons), PhD1, Claire Alison Baker, BSc (Hons)2, Steve Hawkins, MIBiol3, Hugh Simmons, BVSc, MRCVS, MBA, MA3, Timm Konold, DrMedVet, PhD, MRCVS3 and Ben Charles Maddison, BSc (Hons), PhD2

    Abstract

    The transmissible spongiform encephalopathy scrapie of sheep/goats and chronic wasting disease of cervids are associated with environmental reservoirs of infectivity.

    Preventing environmental prions acting as a source of infectivity to healthy animals is of major concern to farms that have had outbreaks of scrapie and also to the health management of wild and farmed cervids.

    Here, an efficient scrapie decontamination protocol was applied to a farm with high levels of environmental contamination with the scrapie agent.

    Post-decontamination, no prion material was detected within samples taken from the farm buildings as determined using a sensitive in vitro replication assay (sPMCA).

    A bioassay consisting of 25 newborn lambs of highly susceptible prion protein genotype VRQ/VRQ introduced into this decontaminated barn was carried out in addition to sampling and analysis of dust samples that were collected during the bioassay.

    Twenty-four of the animals examined by immunohistochemical analysis of lymphatic tissues were scrapie-positive during the bioassay, samples of dust collected within the barn were positive by month 3.

    The data illustrates the difficulty in decontaminating farm buildings from scrapie, and demonstrates the likely contribution of farm dust to the recontamination of these environments to levels that are capable of causing disease.

    snip...

    As in the authors' previous study,12 the decontamination of this sheep barn was not effective at removing scrapie infectivity, and despite the extra measures brought into this study (more effective chemical treatment and removal of sources of dust) the overall rates of disease transmission mirror previous results on this farm. With such apparently effective decontamination (assuming that at least some sPMCA seeding ability is coincident with infectivity), how was infectivity able to persist within the environment and where does infectivity reside? Dust samples were collected in both the bioassay barn and also a barn subject to the same decontamination regime within the same farm (but remaining unoccupied). Within both of these barns dust had accumulated for three months that was able to seed sPMCA, indicating the accumulation of scrapie-containing material that was independent of the presence of sheep that may have been incubating and possibly shedding low amounts of infectivity.

    This study clearly demonstrates the difficulty in removing scrapie infectivity from the farm environment. Practical and effective prion decontamination methods are still urgently required for decontamination of scrapie infectivity from farms that have had cases of scrapie and this is particularly relevant for scrapiepositive goatherds, which currently have limited genetic resistance to scrapie within commercial breeds.24 This is very likely to have parallels with control efforts for CWD in cervids.

    Acknowledgements The authors thank the APHA farm staff, Tony Duarte, Olly Roberts and Margaret Newlands for preparation of the sheep pens and animal husbandry during the study. The authors also thank the APHA pathology team for RAMALT and postmortem examination.

    Funding This study was funded by DEFRA within project SE1865.

    Competing interests None declared.

    https://veterinaryrecord.bmj.com/con...vr.105054.long

    Saturday, January 5, 2019

    Rapid recontamination of a farm building occurs after attempted prion removal

    https://prionprp.blogspot.com/2019/0...-building.html


    kind regards, terry

  2. #12
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    Default Re: Texas Chronic Wasting Disease CWD TSE Prion Symposium 2018 posted January 2019 VI

    Quote Originally Posted by Bang View Post
    There's a well known, well-used processor in Lower Bucks who will not process animals from certain states because of the wasting disease.
    smart man!

    THURSDAY, FEBRUARY 07, 2019

    CWD TSE Prion, and Processing your own meat

    https://chronic-wasting-disease.blog...-your-own.html


    kind regards, terry

  3. #13
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    Default Re: Texas Chronic Wasting Disease CWD TSE Prion Symposium 2018 posted January 2019 VI

    Quote Originally Posted by Yoder View Post
    They think CWD came from a research center in Colorado. They were doing tests with sheep and scrapie which is the sheep version of CWD. They think it jumped to deer or mule deer and spread out from there. It originated in Colorado from what they can tell. Heard this on the Meat Eater podcast with Steve Rinella. He had a biologist on that works in Federal wildlife management. Here's the link if you are interested. Really great info. Pretty scary.

    https://www.themeateater.com/listen/...asting-disease

    ”The occurrence of CWD must be viewed against the contest of the locations in which it occurred. It was an incidental and unwelcome complication of the respective wildlife research programmes. Despite it’s subsequent recognition as a new disease of cervids, therefore justifying direct investigation, no specific research funding was forthcoming. The USDA veiwed it as a wildlife problem and consequently not their province!” page 26.

    https://web.archive.org/web/20060307...m11b/tab01.pdf

    COLORADO THE ORIGIN OF CHRONIC WASTING DISEASE CWD TSE PRION?

    *** Spraker suggested an interesting explanation for the occurrence of CWD. The deer pens at the Foot Hills Campus were built some 30-40 years ago by a Dr. Bob Davis. At or abut that time, allegedly, some scrapie work was conducted at this site. When deer were introduced to the pens they occupied ground that had previously been occupied by sheep.

    IN CONFIDENCE, REPORT OF AN UNCONVENTIONAL SLOW VIRUS DISEASE IN ANIMALS IN THE USA 1989

    http://webarchive.nationalarchives.g...m11b/tab01.pdf

    ALSO, one of the most, if not the most top TSE Prion God in Science today is Professor Adriano Aguzzi, and he recently commented on just this, on a cwd post on my facebook page August 20 at 1:44pm, quote;

    ''it pains me to no end to even comtemplate the possibility, but it seems entirely plausible that CWD originated from scientist-made spread of scrapie from sheep to deer in the colorado research facility. If true, a terrible burden for those involved.'' August 20 at 1:44pm ...end

    P.97: Scrapie transmits to white-tailed deer by the oral route and has a molecular profile similar to chronic wasting disease and distinct from the scrapie inoculum

    Justin Greenlee1, S JO Moore1, Jodi Smith1, M Heather WestGreenlee2 and Robert Kunkle1

    1National Animal Disease Center; Ames, IA USA

    2Iowa State University; Ames, IA USA

    The purpose of this work was to determine susceptibility of white-tailed deer (WTD) to the agent of sheep scrapie and to compare the resultant PrPSc to that of the original inoculum and chronic wasting disease (CWD). We inoculated WTD by a natural route of exposure (concurrent oral and intranasal (IN); n = 5) with a US scrapie isolate. All scrapie-inoculated deer had evidence of PrPSc accumulation. PrPSc was detected in lymphoid tissues at preclinical time points, and deer necropsied after 28 months post-inoculation had clinical signs, spongiform encephalopathy, and widespread distribution of PrPSc in neural and lymphoid tissues. Western blotting (WB) revealed PrPSc with 2 distinct molecular profiles. WB on cerebral cortex had a profile similar to the original scrapie inoculum, whereas WB of brainstem, cerebellum, or lymph nodes revealed PrPSc with a higher profile resembling CWD. Homogenates with the 2 distinct profiles from WTD with clinical scrapie were further passaged to mice expressing cervid prion protein and intranasally to sheep and WTD. In cervidized mice, the 2 inocula have distinct incubation times. Sheep inoculated intranasally with WTD derived scrapie developed disease, but only after inoculation with the inoculum that had a scrapie-like profile. The WTD study is ongoing, but deer in both inoculation groups are positive for PrPSc by rectal mucosal biopsy.

    ***In summary, this work demonstrates that WTD are susceptible to the agent of scrapie, 2 distinct molecular profiles of PrPSc are present in the tissues of affected deer, and inoculum of either profile readily passes to deer.

    https://www.tandfonline.com/doi/full...6.2015.1033248

    *** After a natural route of exposure, 100% of WTD were susceptible to scrapie.

    PO-039: A comparison of scrapie and chronic wasting disease in white-tailed deer Justin Greenlee, Jodi Smith, Eric Nicholson US Dept. Agriculture; Agricultural Research Service, National Animal Disease Center; Ames, IA USA

    http://www.landesbioscience.com/jour...nd-strains.pdf

    also, cwd transmits to pigs by oral route, there should be a declaration of emergency just to change the mad cow feed ban imo!

    Sheep and cattle may be exposed to CWD via common grazing areas with affected deer but so far, appear to be poorly susceptible to mule deer CWD (Sigurdson, 2008). In contrast, cattle are highly susceptible to white-tailed deer CWD and mule deer CWD in experimental conditions but no natural CWD infections in cattle have been reported (Sigurdson, 2008; Hamir et al., 2006). It is not known how susceptible humans are to CWD but given that the prion can be present in muscle, it is likely that humans have been exposed to the agent via consumption of venison (Sigurdson, 2008). Initial experimental research suggests that human susceptibility to CWD is low and there may be a robust species barrier for CWD transmission to humans (Sigurdson, 2008), however the risk appetite for a public health threat may still find this level unacceptable.

    https://assets.publishing.service.go...une2018_v1.pdf

    http://chronic-wasting-disease.blogs...-agent-of.html

    cwd scrapie pigs oral routes

    ***> However, at 51 months of incubation or greater, 5 animals were positive by one or more diagnostic methods. Furthermore, positive bioassay results were obtained from all inoculated groups (oral and intracranial; market weight and end of study) suggesting that swine are potential hosts for the agent of scrapie. <***

    >*** Although the current U.S. feed ban is based on keeping tissues from TSE infected cattle from contaminating animal feed, swine rations in the U.S. could contain animal derived components including materials from scrapie infected sheep and goats. These results indicating the susceptibility of pigs to sheep scrapie, coupled with the limitations of the current feed ban, indicates that a revision of the feed ban may be necessary to protect swine production and potentially human health. <***

    ***> Results: PrPSc was not detected by EIA and IHC in any RPLNs. All tonsils and MLNs were negative by IHC, though the MLN from one pig in the oral <6 month group was positive by EIA. PrPSc was detected by QuIC in at least one of the lymphoid tissues examined in 5/6 pigs in the intracranial <6 months group, 6/7 intracranial >6 months group, 5/6 pigs in the oral <6 months group, and 4/6 oral >6 months group. Overall, the MLN was positive in 14/19 (74%) of samples examined, the RPLN in 8/18 (44%), and the tonsil in 10/25 (40%).

    ***> Conclusions: This study demonstrates that PrPSc accumulates in lymphoid tissues from pigs challenged intracranially or orally with the CWD agent, and can be detected as early as 4 months after challenge. CWD-infected pigs rarely develop clinical disease and if they do, they do so after a long incubation period.

    This raises the possibility that CWD-infected pigs could shed prions into their environment long before they develop clinical disease.

    Furthermore, lymphoid tissues from CWD-infected pigs could present a potential source of CWD infectivity in the animal and human food chains.

    https://www.ars.usda.gov/research/pu...eqNo115=353091

    https://www.ars.usda.gov/research/pr...432011&fy=2017

    https://www.ars.usda.gov/research/pu...eqNo115=337105

    TUESDAY, APRIL 18, 2017

    *** EXTREME USA FDA PART 589 TSE PRION FEED LOOP HOLE STILL EXIST, AND PRICE OF POKER GOES UP ***

    http://usdameatexport.blogspot.com/2...rion-feed.html

    kind regards, terry

  4. #14
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    Default Re: Texas Chronic Wasting Disease CWD TSE Prion Symposium 2018 posted January 2019 VI

    Quote Originally Posted by Delkal View Post
    The much bigger question is can humans get it from eating the deer.
    Researchers say YES from a few places I've been reading.

  5. #15
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    Default Re: Texas Chronic Wasting Disease CWD TSE Prion Symposium 2018 posted January 2019 VI

    Late to this thread, but here's some contributions.

    PA Game Commission page, from October 2018
    https://www.pgc.pa.gov/Wildlife/Wild...ngDisease.aspx

    Latest media converage of the issue
    https://www.pennlive.com/life/2019/0...nsylvania.html
    no size restrictions & screw the limit.

  6. #16
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    Default Re: Texas Chronic Wasting Disease CWD TSE Prion Symposium 2018 posted January 2019 VI

    Was just covered on Phila TV news last week. New to me is they said the deer (family) can have the disease for two years before exhibiting symptoms.
    THAT is a bit scary !

    CDC says there have been no reported cases among humans, but urges be careful.
    Last edited by Bang; February 26th, 2019 at 05:42 PM.
    Legislating to prevent people's acts is fantasy

  7. #17
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    Default Re: Texas Chronic Wasting Disease CWD TSE Prion Symposium 2018 posted January 2019 VI

    Quote Originally Posted by Bang View Post
    Was just covered on Phila TV news last week. New to me is they said the deer (family) can have the disease for two years before exhibiting symptoms.
    THAT is a bit scary !

    CDC says there have been no reported cases among humans, but urges be careful.

    here is what the actual authors at the cdc nih actual said in an email about human cwd cjd...

    *** now, let’s see what the authors said about this casual link, personal communications years ago, and then the latest on the zoonotic potential from CWD to humans from the TOKYO PRION 2016 CONFERENCE.

    see where it is stated NO STRONG evidence. so, does this mean there IS casual evidence ???? “Our conclusion stating that we found no strong evidence of CWD transmission to humans”

    From: TSS (216-119-163-189.ipset45.wt.net)

    Subject: CWD aka MAD DEER/ELK TO HUMANS ???

    Date: September 30, 2002 at 7:06 am PST

    From: "Belay, Ermias"

    To: Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias"

    Sent: Monday, September 30, 2002 9:22 AM

    Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS

    Dear Sir/Madam,

    In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD.. That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.

    Ermias Belay, M.D. Centers for Disease Control and Prevention

    -----Original Message-----

    From: Sent: Sunday, September 29, 2002 10:15 AM

    To: rr26k@nih.gov; rrace@niaid.nih.gov; ebb8@CDC.GOV

    Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS

    Sunday, November 10, 2002 6:26 PM .......snip........end..............TSS

    Thursday, April 03, 2008

    A prion disease of cervids: Chronic wasting disease 2008 1: Vet Res. 2008 Apr 3;39(4):41 A prion disease of cervids: Chronic wasting disease Sigurdson CJ.

    snip...

    *** twenty-seven CJD patients who regularly consumed venison were reported to the Surveillance Center***,

    snip... full text ;

    http://chronic-wasting-disease.blogs...s-chronic.html

    > However, to date, no CWD infections have been reported in people.

    key word here is 'reported'. science has shown that CWD in humans will look like sporadic CJD. SO, how can one assume that CWD has not already transmitted to humans? they can't, and it's as simple as that. from all recorded science to date, CWD has already transmitted to humans, and it's being misdiagnosed as sporadic CJD. ...terry

    *** LOOKING FOR CWD IN HUMANS AS nvCJD or as an ATYPICAL CJD, LOOKING IN ALL THE WRONG PLACES $$$ ***

    *** These results would seem to suggest that CWD does indeed have zoonotic potential, at least as judged by the compatibility of CWD prions and their human PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests that if zoonotic CWD occurred, it would most likely effect those of the PRNP codon 129-MM genotype and that the PrPres type would be similar to that found in the most common subtype of sCJD (MM1).***

    http://www.tandfonline.com/doi/full/...124?src=recsys

    http://www.tandfonline.com/doi/pdf/1...eedAccess=true

    https://wwwnc.cdc.gov/eid/article/20/1/13-0858_article

    MONDAY, FEBRUARY 25, 2019

    MAD DOGS AND ENGLISHMEN BSE, SCRAPIE, CWD, CJD, TSE PRION A REVIEW 2019

    https://bseinquiry.blogspot.com/2019...rapie-cwd.html


    kind regards, terry

  8. #18
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    Default Re: Texas Chronic Wasting Disease CWD TSE Prion Symposium 2018 posted January 2019 VI

    Si vis pacem, para bellum
    μολ ν λαβέ
    What country can preserve its liberties if their rulers are not warned from time to time that their people preserve the spirit of resistance? Let them take arms!

  9. #19
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    Default Re: Texas Chronic Wasting Disease CWD TSE Prion Symposium 2018 posted January 2019 VI

    Chronic Wasting Disease TSE Prion Strains everything in Texas is bigger, better, and badder

    One day in late February, in their laboratory in Fort Collins, Colorado, Wagner and Zabel compared the prions from the brains of CWD-infected deer in Texas with those of elk in Colorado. They want to know if the proteins were all mangled in the same way, or not. “If they are different, this would suggest that we have different strain properties, which is evidence as we're building our case that we might have multiple strains of CWD circulating in the U.S.,” says Wagner.

    Step one is to see if they’re equally easy to destroy using a chemical called guanidine. The shape of a prion dictates everything, including the way it interacts with an animal’s cells and the ease with which chemicals can unfold it.

    “Moment of truth,” said Wagner, as she and Zabel huddled around a computer, waiting for results to come through. When they did, Zabel was surprised.

    “Wow,” he said. “Unlike anything we've seen before.”

    The prions from the Texas deer were a lot harder to destroy than the ones from the Colorado elk. In fact, the guanidine barely damaged them at all. “We’ve never seen that before in any prion strain, which means that it has a completely different structure than we've ever seen before,” says Zabel. And that suggests that it might be a very different kind of chronic wasting disease. The researchers ran the same test on another Texas deer, with the same results.

    SUNDAY, APRIL 14, 2019

    Chronic Wasting Disease TSE Prion Strains everything in Texas is bigger, better, and badder

    https://chronic-wasting-disease.blog...tse-prion.html

    MONDAY, APRIL 15, 2019

    Wisconsin 1,060 WTD tested positive for CWD during 2018 surveillance year April 1 through March 31

    https://chronic-wasting-disease.blog...itive-for.html

    FRIDAY, APRIL 12, 2019

    Sweden Wasting Disease (CWD) discovered on moose in Norrbotten County

    https://chronic-wasting-disease.blog...iscovered.html

    FRIDAY, MARCH 29, 2019

    First Detection of Chronic Wasting Disease in a Wild Red Deer (Cervus elaphus) in Europe

    https://chronic-wasting-disease.blog...c-wasting.html

    THURSDAY, MARCH 14, 2019

    USDA APHIS CDC Cervids: Chronic Wasting Disease Specifics Updated 2019

    https://chronic-wasting-disease.blog...c-wasting.html

    SATURDAY, MARCH 16, 2019

    Chronic Wasting Disease CWD TSE Prion United States of America Update March 16, 2019

    https://chronic-wasting-disease.blog...tse-prion.html

    TUESDAY, MARCH 26, 2019

    USDA ARS 2018 USAHA RESOLUTIONS Investigation of the Role of the Prion Protein Gene in CWD Resistance and Transmission of Disease

    https://chronic-wasting-disease.blog...solutions.html

    WEDNESDAY, APRIL 03, 2019

    Estimating the amount of Chronic Wasting Disease infectivity passing through abattoirs and field slaughter

    https://chronic-wasting-disease.blog...c-wasting.html

    MONDAY, FEBRUARY 25, 2019

    MAD DOGS AND ENGLISHMEN BSE, SCRAPIE, CWD, CJD, TSE PRION A REVIEW 2019

    https://bseinquiry.blogspot.com/2019...rapie-cwd.html

    THURSDAY, OCTOBER 04, 2018

    Cervid to human prion transmission 5R01NS088604-04 Update

    http://grantome.com/grant/NIH/R01-NS088604-04

    http://chronic-wasting-disease.blogs...nsmission.html

    MONDAY, APRIL 01, 2019

    PUBLIC HEALTH U of M launches Chronic Wasting Disease Program to address potential health crisis

    https://chronic-wasting-disease.blog...s-chronic.html

    CHRONIC WASTING DISEASE CONGRESS Serial No. 107-117 May 16, 2002

    CHRONIC WASTING DISEASE

    JOINT OVERSIGHT HEARING BEFORE THE SUBCOMMITTEE ON FORESTS AND FOREST HEALTH JOINT WITH THE SUBCOMMITTEE ON FISHERIES CONSERVATION, WILDLIFE AND OCEANS OF THE COMMITTEE ON RESOURCES U.S. HOUSE OF REPRESENTATIVES ONE HUNDRED SEVENTH CONGRESS SECOND SESSION

    May 16, 2002

    Serial No. 107-117

    https://www.govinfo.gov/content/pkg/...lEG7hxgzWplJlk

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