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  1. #11
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    Default Re: CWD TSE Prion update

    Quote Originally Posted by bogey1 View Post
    Wildlife biologists, are they just like the architects that design houses the WRONG way,
    because they never spent a day in the field, just the classroom?

    Sorry but a great number of Wildlife biologists spend their lives in the field as well as hunting the same forests in their off times. Everything in the world isn’t a conspiracy controlled by the Gov.

    Uncle Ted feels the way he does because he hunts behind his miles high wire fences where he traps everything in his back yard and shoots at close ranges. Closed wire operations also happen to be an excellent way to spread CWD. Im not saying Teds wrong for hunting that way although it’s not for me but he’s isolated himself because millions of dollars have allowed him too.

    If you actually give a shit about CWD and want to form an unbiased knowledge of it then listen to the hunter and author Steven Rinellas pod cast “The Meateater pod cast” where he discusses this and other wildlife topics with other life long hunters, and highly respected independent, state and federal wildlife biologists who have the experience based on thousands of hours of real world study and field time. Don’t worry he’s not some lefty tree hugger douche either.

    https://www.themeateater.com/listen/meateater

    Ted has his opinion and that’s great but knowing him and things he’s said in the past regarding it it’s probably not much more then that.
    Last edited by Hodgie; December 15th, 2018 at 02:21 PM.

  2. #12
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    Default Re: CWD TSE Prion update

    Quote Originally Posted by Hodgie View Post
    Sorry but a great number of Wildlife biologists spend their lives in the field as well as hunting the same forests in their off times.
    I'm sure they do, doesn't mean ALL of them are right, just like the idiot architects/engineers I deal with.

  3. #13
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    Default Re: CWD TSE Prion update

    Quote Originally Posted by bogey1 View Post
    I'm sure they do, doesn't mean ALL of them are right, just like the idiot architects/engineers I deal with.
    Ted Nugent hunts on a fucking fenced in deer farm over corn feeders. His knees are so bad he can hardly walk. I'm sure he knows everything about wildlife.
    "Take the guns first, then worry about due process" Trump

  4. #14
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    Default Re: CWD TSE Prion update

    Quote Originally Posted by Yoder View Post
    I'm sure he knows everything about wildlife.
    I'm sure he does.

  5. #15
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    Exclamation Re: CWD TSE Prion update

    Quote Originally Posted by God's Country View Post
    Do we really need yet another CWD thread from the same OP?

    24 threads started, and 47 posts all CWD related.

    I don't care if the OP wants to beat the CWD drum, but IMO we don't need a new thread every time he reappears.

    ***> 2018 PRION CONFERENCE REPORTS AND ARS USA RESEARCH REPORTS <***

    Scrapie, CWD, tse prion, transmit to pigs by oral route

    ***> However, at 51 months of incubation or greater, 5 animals were positive by one or more diagnostic methods. Furthermore, positive bioassay results were obtained from all inoculated groups (oral and intracranial; market weight and end of study) suggesting that swine are potential hosts for the agent of scrapie. <***

    >*** Although the current U.S. feed ban is based on keeping tissues from TSE infected cattle from contaminating animal feed, swine rations in the U.S. could contain animal derived components including materials from scrapie infected sheep and goats. These results indicating the susceptibility of pigs to sheep scrapie, coupled with the limitations of the current feed ban, indicates that a revision of the feed ban may be necessary to protect swine production and potentially human health. <***


    ***> Results: PrPSc was not detected by EIA and IHC in any RPLNs. All tonsils and MLNs were negative by IHC, though the MLN from one pig in the oral <6 month group was positive by EIA. PrPSc was detected by QuIC in at least one of the lymphoid tissues examined in 5/6 pigs in the intracranial <6 months group, 6/7 intracranial >6 months group, 5/6 pigs in the oral <6 months group, and 4/6 oral >6 months group. Overall, the MLN was positive in 14/19 (74%) of samples examined, the RPLN in 8/18 (44%), and the tonsil in 10/25 (40%).

    ***> Conclusions: This study demonstrates that PrPSc accumulates in lymphoid tissues from pigs challenged intracranially or orally with the CWD agent, and can be detected as early as 4 months after challenge. CWD-infected pigs rarely develop clinical disease and if they do, they do so after a long incubation period.

    This raises the possibility that CWD-infected pigs could shed prions into their environment long before they develop clinical disease.

    Furthermore, lymphoid tissues from CWD-infected pigs could present a potential source of CWD infectivity in the animal and human food chains.

    https://www.ars.usda.gov/research/pu...eqNo115=353091

    https://www.ars.usda.gov/research/pr...432011&fy=2017

    https://www.ars.usda.gov/research/pu...eqNo115=337105

    ***2018***

    Cervid to human prion transmission

    Kong, Qingzhong

    Case Western Reserve University, Cleveland, OH, United States

    Abstract

    Prion disease is transmissible and invariably fatal. Chronic wasting disease (CWD) is the prion disease affecting deer, elk and moose, and it is a widespread and expanding epidemic affecting 22 US States and 2 Canadian provinces so far. CWD poses the most serious zoonotic prion transmission risks in North America because of huge venison consumption (>6 million deer/elk hunted and consumed annually in the USA alone), significant prion infectivity in muscles and other tissues/fluids from CWD-affected cervids, and usually high levels of individual exposure to CWD resulting from consumption of the affected animal among often just family and friends. However, we still do not know whether CWD prions can infect humans in the brain or peripheral tissues or whether clinical/asymptomatic CWD zoonosis has already occurred, and we have no essays to reliably detect CWD infection in humans.

    We hypothesize that:

    (1) The classic CWD prion strain can infect humans at low levels in the brain and peripheral lymphoid tissues;

    (2) The cervid-to-human transmission barrier is dependent on the cervid prion strain and influenced by the host (human) prion protein (PrP) primary sequence;

    (3) Reliable essays can be established to detect CWD infection in humans; and

    (4) CWD transmission to humans has already occurred. We will test these hypotheses in 4 Aims using transgenic (Tg) mouse models and complementary in vitro approaches.

    Aim 1 will prove that the classical CWD strain may infect humans in brain or peripheral lymphoid tissues at low levels by conducting systemic bioassays in a set of humanized Tg mouse lines expressing common human PrP variants using a number of CWD isolates at varying doses and routes. Experimental human CWD samples will also be generated for Aim 3.

    Aim 2 will test the hypothesis that the cervid-to-human prion transmission barrier is dependent on prion strain and influenced by the host (human) PrP sequence by examining and comparing the transmission efficiency and phenotypes of several atypical/unusual CWD isolates/strains as well as a few prion strains from other species that have adapted to cervid PrP sequence, utilizing the same panel of humanized Tg mouse lines as in Aim 1.

    Aim 3 will establish reliable essays for detection and surveillance of CWD infection in humans by examining in details the clinical, pathological, biochemical and in vitro seeding properties of existing and future experimental human CWD samples generated from Aims 1-2 and compare them with those of common sporadic human Creutzfeldt-Jakob disease (sCJD) prions.

    Aim 4 will attempt to detect clinical CWD-affected human cases by examining a significant number of brain samples from prion-affected human subjects in the USA and Canada who have consumed venison from CWD-endemic areas utilizing the criteria and essays established in Aim 3. The findings from this proposal will greatly advance our understandings on the potential and characteristics of cervid prion transmission in humans, establish reliable essays for CWD zoonosis and potentially discover the first case(s) of CWD infection in humans.

    Public Health Relevance

    There are significant and increasing human exposure to cervid prions because chronic wasting disease (CWD, a widespread and highly infectious prion disease among deer and elk in North America) continues spreading and consumption of venison remains popular, but our understanding on cervid-to-human prion transmission is still very limited, raising public health concerns. This proposal aims to define the zoonotic risks of cervid prions and set up and apply essays to detect CWD zoonosis using mouse models and in vitro methods. The findings will greatly expand our knowledge on the potentials and characteristics of cervid prion transmission in humans, establish reliable essays for such infections and may discover the first case(s) of CWD infection in humans.

    Funding Agency

    Agency

    National Institute of Health (NIH)

    http://grantome.com/grant/NIH/R01-NS088604-04

    ZOONOTIC CHRONIC WASTING DISEASE CWD TSE PRION UPDATE

    here is the latest;

    PRION 2018 CONFERENCE

    Oral transmission of CWD into Cynomolgus macaques: signs of atypical disease, prion conversion and infectivity in macaques and bio-assayed transgenic mice

    Hermann M. Schatzl, Samia Hannaoui, Yo-Ching Cheng, Sabine Gilch (Calgary Prion Research Unit, University of Calgary, Calgary, Canada) Michael Beekes (RKI Berlin), Walter Schulz-Schaeffer (University of Homburg/Saar, Germany), Christiane Stahl-Hennig (German Primate Center) & Stefanie Czub (CFIA Lethbridge). To date, BSE is the only example of interspecies transmission of an animal prion disease into humans. The potential zoonotic transmission of CWD is an alarming issue and was addressed by many groups using a variety of in vitro and in vivo experimental systems. Evidence from these studies indicated a substantial, if not absolute, species barrier, aligning with the absence of epidemiological evidence suggesting transmission into humans. Studies in non-human primates were not conclusive so far, with oral transmission into new-world monkeys and no transmission into old-world monkeys. Our consortium has challenged 18 Cynomolgus macaques with characterized CWD material, focusing on oral transmission with muscle tissue. Some macaques have orally received a total of 5 kg of muscle material over a period of 2 years.

    After 5-7 years of incubation time some animals showed clinical symptoms indicative of prion disease, and prion neuropathology and PrPSc deposition were detected in spinal cord and brain of some euthanized animals. PrPSc in immunoblot was weakly detected in some spinal cord materials and various tissues tested positive in RT-QuIC, including lymph node and spleen homogenates. To prove prion infectivity in the macaque tissues, we have intracerebrally inoculated 2 lines of transgenic mice, expressing either elk or human PrP. At least 3 TgElk mice, receiving tissues from 2 different macaques, showed clinical signs of a progressive prion disease and brains were positive in immunoblot and RT-QuIC. Tissues (brain, spinal cord and spleen) from these and pre-clinical mice are currently tested using various read-outs and by second passage in mice. Transgenic mice expressing human PrP were so far negative for clear clinical prion disease (some mice >300 days p.i.). In parallel, the same macaque materials are inoculated into bank voles.

    Taken together, there is strong evidence of transmissibility of CWD orally into macaques and from macaque tissues into transgenic mouse models, although with an incomplete attack rate.

    The clinical and pathological presentation in macaques was mostly atypical, with a strong emphasis on spinal cord pathology.

    Our ongoing studies will show whether the transmission of CWD into macaques and passage in transgenic mice represents a form of non-adaptive prion amplification, and whether macaque-adapted prions have the potential to infect mice expressing human PrP.

    The notion that CWD can be transmitted orally into both new-world and old-world non-human primates asks for a careful reevaluation of the zoonotic risk of CWD..

    ***> The notion that CWD can be transmitted orally into both new-world and old-world non-human primates asks for a careful reevaluation of the zoonotic risk of CWD. <***

    https://prion2018.org/

    READING OVER THE PRION 2018 ABSTRACT BOOK, LOOKS LIKE THEY FOUND THAT from this study ;

    P190 Human prion disease mortality rates by occurrence of chronic wasting disease in freeranging cervids, United States

    Abrams JY (1), Maddox RA (1), Schonberger LB (1), Person MK (1), Appleby BS (2), Belay ED (1) (1) Centers for Disease Control and Prevention (CDC), National Center for Emerging and Zoonotic Infectious Diseases, Atlanta, GA, USA (2) Case Western Reserve University, National Prion Disease Pathology Surveillance Center (NPDPSC), Cleveland, OH, USA..

    SEEMS THAT THEY FOUND Highly endemic states had a higher rate of prion disease mortality compared to non-CWD states.

    AND ANOTHER STUDY;

    P172 Peripheral Neuropathy in Patients with Prion Disease

    Wang H(1), Cohen M(1), Appleby BS(1,2) (1) University Hospitals Cleveland Medical Center, Cleveland, Ohio (2) National Prion Disease Pathology Surveillance Center, Cleveland, Ohio..

    IN THIS STUDY, THERE WERE autopsy-proven prion cases from the National Prion Disease Pathology Surveillance Center that were diagnosed between September 2016 to March 2017,

    AND

    included 104 patients. SEEMS THEY FOUND THAT The most common sCJD subtype was MV1-2 (30%), followed by MM1-2 (20%),

    AND

    THAT The Majority of cases were male (60%), AND half of them had exposure to wild game.

    snip...see more on Prion 2017 Macaque study from Prion 2017 Conference and other updated science on cwd tse prion zoonosis below...terry

    https://prion2018.org/wp-content/upl...05/program.pdf

    https://prion2018.org/

    THURSDAY, OCTOBER 04, 2018

    Cervid to human prion transmission 5R01NS088604-04 Update

    http://chronic-wasting-disease.blogs...nsmission.html

    SUNDAY, DECEMBER 02, 2018

    CWD TSE PRION, REGULATORY LEGISLATION, PAY TO PLAY, and The SPREAD of Chronic Wasting Disease

    https://chronic-wasting-disease.blog...gislation.html

    MONDAY, DECEMBER 10, 2018

    Wisconsin DATCP Confirms 11 additional animals from a deer farm in Washington County tested positive for CWD TSE Prion

    https://chronic-wasting-disease.blog...dditional.html

    FRIDAY, DECEMBER 14, 2018

    Wisconsin Hundreds Of Escapes From State Deer Farms Reported Since 2013 December 14, 2018

    https://chronic-wasting-disease.blog...apes-from.html

    WEDNESDAY, DECEMBER 12, 2018

    Alberta Liberal MLA David Swann supports AFN resolution calling for the phasing out of game farms to help combat CWD

    https://chronic-wasting-disease.blog...vid-swann.html

    MONDAY, DECEMBER 10, 2018

    BOONE AND CROCKETT CLUB POSITION STATEMENT CHRONIC WASTING DISEASE AND THE TRANSPORTATION OF LIVE CERVIDS

    https://chronic-wasting-disease.blog...-position.html

    FRIDAY, DECEMBER 14, 2018

    Norway, Nordfjella VKM 2018 16 Factors that can contribute to spread of CWD TSE Prion UPDATE December 14, 2018

    https://vkm.no/download/18.696229a71...ead%202018.pdf

    https://chronic-wasting-disease.blog...6-factors.html

    SATURDAY, DECEMBER 15, 2018

    Tennessee Preliminarily Detects Ten Chronic Wasting Disease Cases; Enacts CWD Response Plan Friday, December 14, 2018

    https://chronic-wasting-disease.blog...tects-ten.html

    FRIDAY, DECEMBER 14, 2018

    Michigan CWD TSE Prion Climbs To 106 Cases To Date December 14, 2018

    https://chronic-wasting-disease.blog...bs-to-106.html

    WEDNESDAY, DECEMBER 12, 2018

    Texas TPWD TAHC Chronic Wasting Disease CWD TSE Prion 133 Cases To Date 2018 11/30/2018 Breeder Release Site Medina Facility

    https://chronic-wasting-disease.blog...g-disease.html

    MONDAY, DECEMBER 10, 2018

    Wisconsin DATCP Confirms 11 additional animals from a deer farm in Washington County tested positive for CWD TSE Prion

    https://chronic-wasting-disease.blog...dditional.html

    https://chronic-wasting-disease.blog...apes-from.html


    Terry S. Singeltary Sr.

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