If you are really nervous, there are alternatives. At Winchester VA you can take US 522 N to PA and your exposure to MD is about two miles, but watch the reduced speed limit as you go thru MD. Or the Western alternatives. At Wytheville VA take I-77 to I-79 to I-70 in PA then East on I-76 (tolls) with a shortcut on US 19 in W VA if you wish. Alternately at Nashville TN, take I-65 North to I-64 to I-79 then as above. DO NOT take I-68 East out of W VA as that hits MD big time! On this route there is a KY Parkway (Bluegrass Pkwy) that cuts over at Elizabeth and goes thru Bourbon country so that could cause delays depending on your preferences (or not)