I have shot a fair amount of handgun calibers over the years. But eventually I realized that I did not need large calibers for carry/home defense. I am now of the opinion that .22lr, .22 mag, .32 acp, .327 mag, .32 H&R mag, .380 acp, 9mm and .38 are all that is needed by most people. Learn to shoot a caliber well and you are better off than having a large caliber that you do not shoot well. The important thing is shot placement. Can you put a double tap in center mass? Do you feel confident in the weapon you carry? Because if you are accurate with the gun you carry, you are doing well.